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Resetting the Stress System with a Mifepristone Challenge
Psychotic depression is characterized by elevated circulating cortisol, and high daily doses of the glucocorticoid/progesterone antagonist mifepristone for 1 week are required for significant improvement. Using a rodent model, we find that such high doses of mifepristone are needed because the antag...
Autores principales: | Dalm, Sergiu, Karssen, Adriaan M., Meijer, Onno C., Belanoff, Joseph K., de Kloet, E. Ronald |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469632/ https://www.ncbi.nlm.nih.gov/pubmed/30173378 http://dx.doi.org/10.1007/s10571-018-0614-5 |
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