Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

Simultaneous measurement of cell lineage and cell fates is a longstanding goal in biomedicine. Here we describe EMBLEM, a strategy to track cell lineage using endogenous mitochondrial DNA variants in ATAC-seq data. We show that somatic mutations in mitochondrial DNA can reconstruct cell lineage rela...

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Detalles Bibliográficos
Autores principales: Xu, Jin, Nuno, Kevin, Litzenburger, Ulrike M, Qi, Yanyan, Corces, M Ryan, Majeti, Ravindra, Chang, Howard Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469926/
https://www.ncbi.nlm.nih.gov/pubmed/30958261
http://dx.doi.org/10.7554/eLife.45105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469926/
https://www.ncbi.nlm.nih.gov/pubmed/30958261
http://dx.doi.org/10.7554/eLife.45105

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