Loss of PKM2 in Lgr5(+) intestinal stem cells promotes colitis-associated colorectal cancer

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated t...

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Detalles Bibliográficos
Autores principales: Kim, Yeji, Lee, Yong-Soo, Kang, Sung Wan, Kim, Seungil, Kim, Tae-Young, Lee, Su-Hyun, Hwang, Sung Wook, Kim, Jihun, Kim, Eun Na, Ju, Jin-Sung, Park, Yun-Yong, Kweon, Mi-Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470145/
https://www.ncbi.nlm.nih.gov/pubmed/30996297
http://dx.doi.org/10.1038/s41598-019-42707-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470145/
https://www.ncbi.nlm.nih.gov/pubmed/30996297
http://dx.doi.org/10.1038/s41598-019-42707-8

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