Cargando…

Loss of PKM2 in Lgr5(+) intestinal stem cells promotes colitis-associated colorectal cancer

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yeji, Lee, Yong-Soo, Kang, Sung Wan, Kim, Seungil, Kim, Tae-Young, Lee, Su-Hyun, Hwang, Sung Wook, Kim, Jihun, Kim, Eun Na, Ju, Jin-Sung, Park, Yun-Yong, Kweon, Mi-Na
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470145/ https://www.ncbi.nlm.nih.gov/pubmed/30996297 http://dx.doi.org/10.1038/s41598-019-42707-8

Ejemplares similares

Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
por: Kim, Yeji, et al.
Publicado: (2020)

Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development
por: Kim, Seungil, et al.
Publicado: (2021)

LKB1 in Intestinal Epithelial Cells Regulates Bile Acid Metabolism by Modulating FGF15/19 Production
por: Kim, Yeji, et al.
Publicado: (2021)

A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon
por: Kim, Tae-Young, et al.
Publicado: (2021)

Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review
por: Hwang, Sung Wook, et al.
Publicado: (2023)

Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells
por: Lee, Yong-Soo, et al.
Publicado: (2021)

High-Fat Foods and FODMAPs Containing Gluten Foods Primarily Contribute to Symptoms of Irritable Bowel Syndrome in Korean Adults
por: Na, Woori, et al.
Publicado: (2021)

Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection
por: Kim, Seungil, et al.
Publicado: (2023)

Vacuolar H(+)-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling
por: Son, Sung Wook, et al.
Publicado: (2019)

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
por: Cha, Pu-Hyeon, et al.
Publicado: (2020)

Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
por: Sung, You-Na, et al.
Publicado: (2021)

The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation
por: Kim, Yeji, et al.
Publicado: (2017)

KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
por: Varlı, Mücahit, et al.
Publicado: (2023)

p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations
por: Sung, You-Na, et al.
Publicado: (2022)

The Pivotal Role of Long Noncoding RNA RAB5IF in the Proliferation of Hepatocellular Carcinoma via LGR5 Mediated β-Catenin and c-Myc Signaling
por: Koo, Ja Il, et al.
Publicado: (2019)

Combined Hepatic and Splenic Abscesses in a Patient with Ulcerative Colitis
por: Ji, Jeong-Seon, et al.
Publicado: (2007)

Expression profile of intestinal stem cell markers in colitis-associated carcinogenesis
por: Kim, Hye Sung, et al.
Publicado: (2017)

Anoctamin 1/TMEM16A controls intestinal Cl(−) secretion induced by carbachol and cholera toxin
por: Lee, Byeongjun, et al.
Publicado: (2019)

Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin
por: Jun, Yu Kyung, et al.
Publicado: (2023)

High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer
por: Kim, Jeong Eun, et al.
Publicado: (2021)

Gut microbiota alterations in critically Ill patients with carbapenem-resistant Enterobacteriaceae colonization: A clinical analysis
por: Baek, Moon Seong, et al.
Publicado: (2023)

Usefulness of the Cytomegalovirus Antigenemia Assay in Patients With Ulcerative Colitis
por: Chun, Jaeyoung, et al.
Publicado: (2015)

Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer
por: Kim, Dalyong, et al.
Publicado: (2017)

Primary tumor location predicts poor clinical outcome with cetuximab in RAS wild-type metastatic colorectal cancer
por: Kim, Dalyong, et al.
Publicado: (2017)

TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease
por: Lee, Chansu, et al.
Publicado: (2021)

Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers
por: Lee, Hyun Ju, et al.
Publicado: (2021)

Effects of long-term Teatment of Captopril and Enalapril on Rat Intestinal Angiotenisin Converting Enzyme Specific Activities
por: Song, In Sung, et al.
Publicado: (1994)

Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis
por: Lee, June-Chul, et al.
Publicado: (2017)

Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
por: Choi, Jae-Ki, et al.
Publicado: (2018)

Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis
por: Kim, Hyesung, et al.
Publicado: (2022)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
por: Lee, Joo-Hyeon, et al.
Publicado: (2017)

Differences in Blood Loss According to Hemostatic Method in the Excision of Giant Neurofibroma
por: Kim, Tae-Gon, et al.
Publicado: (2012)

Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance
por: Soh, Jae Seung, et al.
Publicado: (2019)

Evaluation of Oral Nutritional Supplementation in the Management of Frailty among the Elderly at Facilities of Community Care for the Elderly
por: Na, Woori, et al.
Publicado: (2021)

Remission of diffuse ulcerative duodenitis in a patient with ulcerative colitis after infliximab therapy: a case study and review of the literature
por: Choi, Yong-Sung, et al.
Publicado: (2019)

A Case of Intestinal Behcet's Disease Similar to Crohn's Colitis
por: Kim, Eun-Sun, et al.
Publicado: (2007)

Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis
por: Bae, Ui-Jin, et al.
Publicado: (2022)

Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition
por: Kim, Joong Sun, et al.
Publicado: (2017)

Brief Education on Microvasculature and Pit Pattern for Trainees Significantly Improves Estimation of the Invasion Depth of Colorectal Tumors
por: Kim, Joon Sung, et al.
Publicado: (2014)

Isolation of a novel species in the genus Cupriavidus from a patient with sepsis using whole genome sequencing
por: Kweon, Oh Joo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_86uc80gb919lrsrl6kaufntqmp