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The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43 undergoes a vast array of post-translational modifications, including phosphorylation, acetylation, and cleavage. Many of these alterations may directly contribute to the pathogenesis of TDP-43 proteinopathies, which in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470282/ https://www.ncbi.nlm.nih.gov/pubmed/31031584 http://dx.doi.org/10.3389/fnins.2019.00335 |