Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators

Several studies by our group and others have determined that expression levels of Bcl-2 and/or Bcl-xL, pro-survival molecules which are associated with chemoresistance, are elevated in patients with muscle invasive bladder cancer (MI-BC). The goal of this study was to determine whether combining Oba...

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Detalles Bibliográficos
Autores principales: Steele, Thomas M., Talbott, George C., Sam, Anhao, Tepper, Clifford G., Ghosh, Paramita M., Vinall, Ruth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470498/
https://www.ncbi.nlm.nih.gov/pubmed/30875757
http://dx.doi.org/10.3390/ijms20061285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470498/
https://www.ncbi.nlm.nih.gov/pubmed/30875757
http://dx.doi.org/10.3390/ijms20061285

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