Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

As a cellular bile acid sensor, farnesoid X receptor (FXR) and the membrane G-coupled receptor (GPBAR1) participate in maintaining bile acid, lipid, and glucose homeostasis. To date, several selective and dual agonists have been developed as promising pharmacological approach to metabolic disorders,...

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Detalles Bibliográficos
Autores principales: Finamore, Claudia, Baronissi, Giuliana, Marchianò, Silvia, Di Leva, Francesco Saverio, Carino, Adriana, Monti, Maria Chiara, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano, Sepe, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470523/
https://www.ncbi.nlm.nih.gov/pubmed/30884797
http://dx.doi.org/10.3390/molecules24061043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470523/
https://www.ncbi.nlm.nih.gov/pubmed/30884797
http://dx.doi.org/10.3390/molecules24061043

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