Design and Synthesis of Matrine Derivatives as Novel Anti-Pulmonary Fibrotic Agents via Repression of the TGFβ/Smad Pathway

A total of 18 matrine derivatives were designed, synthesized, and evaluated for their inhibitory effect against TGF-β1-induced total collagen accumulation in human fetal lung fibroblast MRC-5 cell lines. Among them, compound 3f displayed the most potent anti-fibrotic activity (IC(50) = 3.3 ± 0.3 μM)...

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Detalles Bibliográficos
Autores principales: Li, Lingyu, Ma, Liyan, Wang, Dongchun, Jia, Hongmei, Yu, Meng, Gu, Yucheng, Shang, Hai, Zou, Zhongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470603/
https://www.ncbi.nlm.nih.gov/pubmed/30897818
http://dx.doi.org/10.3390/molecules24061108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470603/
https://www.ncbi.nlm.nih.gov/pubmed/30897818
http://dx.doi.org/10.3390/molecules24061108

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