Tenofovir Hot-Melt Granulation using Gelucire(®) to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV

Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire(®) (or a mixture of different Gelucire(®)) to obtain drug-loaded granu...

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Detalles Bibliográficos
Autores principales: Notario-Pérez, Fernando, Cazorla-Luna, Raúl, Martín-Illana, Araceli, Ruiz-Caro, Roberto, Peña, Juan, Veiga, María-Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470605/
https://www.ncbi.nlm.nih.gov/pubmed/30897790
http://dx.doi.org/10.3390/pharmaceutics11030137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470605/
https://www.ncbi.nlm.nih.gov/pubmed/30897790
http://dx.doi.org/10.3390/pharmaceutics11030137

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