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Tenofovir Hot-Melt Granulation using Gelucire(®) to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV
Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire(®) (or a mixture of different Gelucire(®)) to obtain drug-loaded granu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470605/ https://www.ncbi.nlm.nih.gov/pubmed/30897790 http://dx.doi.org/10.3390/pharmaceutics11030137 |