Enantioselective Synthesis of the Ethyl Analog of the Marine Alkaloid Haliclorensin C

The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of the ethyl analog of the macrocyclic marine alkaloid haliclorensin C (compound 5) are reported. Amino alcohol 3, generated by a LiNH(2)BH(3)-promoted reductive ring-opening/debenzylation sequence from...

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Detalles Bibliográficos
Autores principales: Guignard, Guillaume, Llor, Núria, Pubill, David, Bosch, Joan, Amat, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470606/
https://www.ncbi.nlm.nih.gov/pubmed/30889939
http://dx.doi.org/10.3390/molecules24061069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470606/
https://www.ncbi.nlm.nih.gov/pubmed/30889939
http://dx.doi.org/10.3390/molecules24061069

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