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Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets. Voltage-gated sodium channels (Na(V)) are often targeted by these peptides to allosterically promote opening or closing of the ch...

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Detalles Bibliográficos
Autores principales: Cardoso, Fernanda C., Lewis, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470632/
https://www.ncbi.nlm.nih.gov/pubmed/31031623
http://dx.doi.org/10.3389/fphar.2019.00366