Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations

Chlorotoxin (CTX) is a 36–amino acid peptide with eight Cys residues that forms four disulfide bonds. It has high affinity for the glioma-specific chloride channel and matrix metalloprotease-2. Structural and binding properties of CTX analogs with various Cys residue substitutions with l-α-aminobuty...

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Detalles Bibliográficos
Autores principales: Gregory, Andrew J., Voit-Ostricki, Leah, Lovas, Sándor, Watts, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470725/
https://www.ncbi.nlm.nih.gov/pubmed/30871150
http://dx.doi.org/10.3390/ijms20061261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470725/
https://www.ncbi.nlm.nih.gov/pubmed/30871150
http://dx.doi.org/10.3390/ijms20061261

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