Facile Conversion of syn‐[Fe(IV)(O)(TMC)](2+) into the anti Isomer via Meunier's Oxo–Hydroxo Tautomerism Mechanism

The syn and anti isomers of [Fe(IV)(O)(TMC)](2+) (TMC=tetramethylcyclam) represent the first isolated pair of synthetic non‐heme oxoiron(IV) complexes with identical ligand topology, differing only in the position of the oxo unit bound to the iron center. Both isomers have previously been characterized. Reported here is that the syn isomer [Fe(IV)(O(syn))(TMC)(NCMe)](2+) (2) converts into its anti form [Fe(IV)(O(anti))(TMC)(NCMe)](2+) (1) in MeCN, an isomerization facilitated by water and monitored most readily by (1)H NMR and Raman spectroscopy. Indeed, when H(2) (18)O is introduced to 2, the nascent 1 becomes (18)O‐labeled. These results provide compelling evidence for a mechanism involving direct binding of a water molecule trans to the oxo atom in 2 with subsequent oxo–hydroxo tautomerism for its incorporation as the oxo atom of 1. The nonplanar nature of the TMC supporting ligand makes this isomerization an irreversible transformation, unlike for their planar heme counterparts.