Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin‐Targeted Conjugate

This work takes advantage of one of the hallmarks of cancer, that is, the presence of tumor infiltrating cells of the immune system and leukocyte‐secreted enzymes, to promote the activation of an anticancer drug at the tumor site. The peptidomimetic integrin ligand cyclo(DKP‐RGD) was found to accumu...

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Detalles Bibliográficos
Autores principales: Raposo Moreira Dias, André, Pina, Arianna, Dean, Amelia, Lerchen, Hans‐Georg, Caruso, Michele, Gasparri, Fabio, Fraietta, Ivan, Troiani, Sonia, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Dal Corso, Alberto, Gennari, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471013/
https://www.ncbi.nlm.nih.gov/pubmed/30452790
http://dx.doi.org/10.1002/chem.201805447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471013/
https://www.ncbi.nlm.nih.gov/pubmed/30452790
http://dx.doi.org/10.1002/chem.201805447

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