Cargando…

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin‐Targeted Conjugate

This work takes advantage of one of the hallmarks of cancer, that is, the presence of tumor infiltrating cells of the immune system and leukocyte‐secreted enzymes, to promote the activation of an anticancer drug at the tumor site. The peptidomimetic integrin ligand cyclo(DKP‐RGD) was found to accumu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raposo Moreira Dias, André, Pina, Arianna, Dean, Amelia, Lerchen, Hans‐Georg, Caruso, Michele, Gasparri, Fabio, Fraietta, Ivan, Troiani, Sonia, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Dal Corso, Alberto, Gennari, Cesare
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471013/ https://www.ncbi.nlm.nih.gov/pubmed/30452790 http://dx.doi.org/10.1002/chem.201805447

Ejemplares similares

Multivalency Increases the Binding Strength of RGD Peptidomimetic‐Paclitaxel Conjugates to Integrin α(V)β(3)
por: Raposo Moreira Dias, André, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of RGD and isoDGR–Monomethyl Auristatin Conjugates Targeting Integrin α(V)β(3)
por: Raposo Moreira Dias, André, et al.
Publicado: (2019)

Tumor Targeting with an isoDGR–Drug Conjugate
por: Zanella, Simone, et al.
Publicado: (2017)

Investigating the Interaction of Cyclic RGD Peptidomimetics with α(V)β(6) Integrin by Biochemical and Molecular Docking Studies
por: Civera, Monica, et al.
Publicado: (2017)

Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting α(v)β(3) Integrin and VEGF Receptors**
por: Zanella, Simone, et al.
Publicado: (2015)

Insights into the Binding of Cyclic RGD Peptidomimetics to α(5)β(1) Integrin by using Live‐Cell NMR And Computational Studies
por: Guzzetti, Ileana, et al.
Publicado: (2016)

Advanced Pyrrolidine‐Carbamate Self‐Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Release
por: Dal Corso, Alberto, et al.
Publicado: (2022)

Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase
por: Zhu, Jing, et al.
Publicado: (2023)

Visible Light-Promoted β-Functionalization of Carbonyl Compounds in the Presence of Organic Dyes
por: Dolcini, Luigi, et al.
Publicado: (2023)

Caspase-1 interdomain linker cleavage is required for pyroptosis
por: Ball, Daniel P, et al.
Publicado: (2020)

Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia
por: Domon, Hisanori, et al.
Publicado: (2021)

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
por: Fu, Zhirong, et al.
Publicado: (2020)

Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors
por: Zanella, Simone, et al.
Publicado: (2019)

Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity
por: Maiorani, Orlando, et al.
Publicado: (2017)

Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates
por: Schuster, Sabine, et al.
Publicado: (2022)

Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
por: Borbély, Adina, et al.
Publicado: (2019)

OR19-05 Steroid:Corticosteroid-Binding Globulin Interactions; Effects of Neutrophil Elastase Cleavage, Pyrexia and Acidosis
por: Meyer, Emily Jane, et al.
Publicado: (2020)

Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers
por: Kellnerová, Sára, et al.
Publicado: (2023)

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability
por: Fu, Zhirong, et al.
Publicado: (2018)

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting
por: Bodero, Lizeth, et al.
Publicado: (2018)

Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway
por: Krotova, Karina, et al.
Publicado: (2020)

A disulfide-based linker for thiol–norbornene conjugation: formation and cleavage of hydrogels by the use of light
por: Lunzer, Markus, et al.
Publicado: (2022)

Oxidative Desymmetrization Enables the Concise Synthesis of a trans‐Cyclooctene Linker for Bioorthogonal Bond Cleavage
por: Kuba, Walter, et al.
Publicado: (2022)

Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model
por: Pivetta, Eliana, et al.
Publicado: (2016)

Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds
por: Panzeri, Silvia, et al.
Publicado: (2020)

Neutrophil elastase in bronchiectasis
por: Gramegna, Andrea, et al.
Publicado: (2017)

The Origin and Evolution of the Plant Cell Surface: Algal Integrin-Associated Proteins and a New Family of Integrin-Like Cytoskeleton-ECM Linker Proteins
por: Becker, Burkhard, et al.
Publicado: (2015)

Synthesis of New Branched 2-Nitroimidazole as a Hypoxia Sensitive Linker for Ligand-Targeted Drugs of Paclitaxel
por: Zhang, Qiumeng, et al.
Publicado: (2018)

Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index
por: Shao, Ting, et al.
Publicado: (2020)

Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors
por: Lerchen, Hans-Georg, et al.
Publicado: (2023)

Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils
Publicado: (1989)

Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis
por: Wu, Siyu, et al.
Publicado: (2019)

SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions
por: Bhattacharyya, Chandrika, et al.
Publicado: (2021)

Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy
por: Chen, Liyu, et al.
Publicado: (2021)

Tetrazine‐Triggered Bioorthogonal Cleavage of trans‐Cyclooctene‐Caged Phenols Using a Minimal Self‐Immolative Linker Strategy
por: Keppel, Patrick, et al.
Publicado: (2022)

The Natural Polypeptides as Significant Elastase Inhibitors
por: Ahmad, Shabir, et al.
Publicado: (2020)

Neutrophil Elastase and Chronic Lung Disease
por: Voynow, Judith A., et al.
Publicado: (2021)

Neutrophil Elastase Defects in Congenital Neutropenia
por: Rydzynska, Zuzanna, et al.
Publicado: (2021)

Flavonoids as inhibitors of human neutrophil elastase
por: Jakimiuk, Katarzyna, et al.
Publicado: (2021)

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination
por: Kramer, Carsten Sven, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3jdvd42u9ans1ihj0qaj9f0vtg