Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8(+) T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia

On healthy cells the non-classical HLA class Ib molecule HLA-E displays the cognate ligand for the NK cell receptor NKG2A/CD94 when bound to HLA class I signal peptide sequences. In a pathogenic situation when HLA class I is absent, HLA-E is bound to a diverse set of peptides and enables the stimula...

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Detalles Bibliográficos
Autores principales: Pump, Wiebke C., Kraemer, Thomas, Huyton, Trevor, Hò, Gia-Gia T., Blasczyk, Rainer, Bade-Doeding, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471057/
https://www.ncbi.nlm.nih.gov/pubmed/30909402
http://dx.doi.org/10.3390/ijms20061454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471057/
https://www.ncbi.nlm.nih.gov/pubmed/30909402
http://dx.doi.org/10.3390/ijms20061454

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