Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides

Protein phosphatase‐1 (PP1)‐disrupting peptides (PDPs) are selective chemical modulators of PP1 that liberate the active PP1 catalytic subunit from regulatory proteins; thus allowing the dephosphorylation of nearby substrates. We have optimized the original cell‐active PDP3 for enhanced stability, a...

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Detalles Bibliográficos
Autores principales: Wang, Yansong, Hoermann, Bernhard, Pavic, Karolina, Trebacz, Malgorzata, Rios, Pablo, Köhn, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471087/
https://www.ncbi.nlm.nih.gov/pubmed/30338897
http://dx.doi.org/10.1002/cbic.201800541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471087/
https://www.ncbi.nlm.nih.gov/pubmed/30338897
http://dx.doi.org/10.1002/cbic.201800541

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