Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents

A new series of 5-(3,5-dinitrophenyl)-1,3,4-thiadiazole derivatives were prepared and evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds 9, 10, 13, and 16 showed strong and broad-spectrum antimicrobial activity comparable to Amoxicillin and Fluconazole as...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Naggar, Mohamed, Sallam, Hanan A., Shaban, Safaa S., Abdel-Wahab, Salwa S., E. Amr, Abd El-Galil, Azab, Mohammad E., Nossier, Eman S., Al-Omar, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471095/
https://www.ncbi.nlm.nih.gov/pubmed/30889918
http://dx.doi.org/10.3390/molecules24061066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471095/
https://www.ncbi.nlm.nih.gov/pubmed/30889918
http://dx.doi.org/10.3390/molecules24061066

Ejemplares similares