Simulation-Based Analysis of the Impact of Renal Impairment on the Pharmacokinetics of Highly Metabolized Compounds

Renal impairment (RI) is a highly prevalent disease which can alter the pharmacokinetics (PK) of xenobiotics, including those that are predominately metabolized. The expression and activity of drug metabolizing enzymes (DMEs) and protein binding of compounds has been demonstrated to be affected in R...

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Detalles Bibliográficos
Autores principales: Follman, Kristin E., Morris, Marilyn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471170/
https://www.ncbi.nlm.nih.gov/pubmed/30832339
http://dx.doi.org/10.3390/pharmaceutics11030105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471170/
https://www.ncbi.nlm.nih.gov/pubmed/30832339
http://dx.doi.org/10.3390/pharmaceutics11030105

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