Developing Small‐Molecule Inhibitors of HECT‐Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities

The ubiquitin system regulates countless physiological and disease‐associated processes and has emerged as an attractive entryway for therapeutic efforts. With over 600 members in the human proteome, ubiquitin ligases are the most diverse class of ubiquitylation enzymes and pivotal in encoding speci...

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Detalles Bibliográficos
Autores principales: Chen, Dan, Gehringer, Matthias, Lorenz, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471174/
https://www.ncbi.nlm.nih.gov/pubmed/30088849
http://dx.doi.org/10.1002/cbic.201800321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471174/
https://www.ncbi.nlm.nih.gov/pubmed/30088849
http://dx.doi.org/10.1002/cbic.201800321

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