LC478, a Novel Di-Substituted Adamantyl Derivative, Enhances the Oral Bioavailability of Docetaxel in Rats

P-glycoprotein (P-gp)-mediated efflux of docetaxel in the gastrointestinal tract mainly impedes its oral chemotherapy. Recently, LC478, a novel di-substituted adamantyl derivative, was identified as a non-cytotoxic P-gp inhibitor in vitro. Here, we assessed whether LC478 enhances the oral bioavailab...

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Detalles Bibliográficos
Autores principales: Han, Seung Yon, Lu, Qili, Lee, Kyeong, Choi, Young Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471177/
https://www.ncbi.nlm.nih.gov/pubmed/30897775
http://dx.doi.org/10.3390/pharmaceutics11030135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471177/
https://www.ncbi.nlm.nih.gov/pubmed/30897775
http://dx.doi.org/10.3390/pharmaceutics11030135

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