Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation

The purpose of this study is to develop a solid dispersion system with improved dissolution, absorption, and patient compliance of poorly water-soluble celecoxib (CXB). Instead of sodium lauryl sulfate (SLS), an anionic surfactant used in the marketed product (Celebrex(®)), solubilization was perfor...

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Detalles Bibliográficos
Autores principales: Kwon, Hyeok Jin, Heo, Eun-Ji, Kim, Young-Hwan, Kim, Sarah, Hwang, Young-Ha, Byun, Ji-Mi, Cheon, Se Hyeop, Park, Sang Yeob, Kim, Dong Yun, Cho, Kwan Hyung, Maeng, Han-Joo, Jang, Dong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471285/
https://www.ncbi.nlm.nih.gov/pubmed/30897776
http://dx.doi.org/10.3390/pharmaceutics11030136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471285/
https://www.ncbi.nlm.nih.gov/pubmed/30897776
http://dx.doi.org/10.3390/pharmaceutics11030136

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