Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study

We have synthesized quinoxaline analogs (1–25), characterized by (1)H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC(50) = 38.68 ± 4.42 µM). The most poten...

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Detalles Bibliográficos
Autores principales: Almandil, Noor Barak, Taha, Muhammad, Farooq, Rai Khalid, Alhibshi, Amani, Ibrahim, Mohamed, Anouar, El Hassane, Gollapalli, Mohammed, Rahim, Fazal, Nawaz, Muhammad, Shah, Syed Adnan Ali, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471342/
https://www.ncbi.nlm.nih.gov/pubmed/30871147
http://dx.doi.org/10.3390/molecules24061002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471342/
https://www.ncbi.nlm.nih.gov/pubmed/30871147
http://dx.doi.org/10.3390/molecules24061002

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