Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors

Metallo-β-lactamases (MβLs) are the target enzymes of β-lactam antibiotic resistance, and there are no effective inhibitors against MβLs available for clinic so far. In this study, thirteen halogen-substituted triazolethioacetamides were designed and synthesized as a potent skeleton of MβLs inhibito...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yilin, Yan, Yong, Liang, Lufan, Feng, Jie, Wang, Xuejun, Li, Li, Yang, Kewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471427/
https://www.ncbi.nlm.nih.gov/pubmed/30934584
http://dx.doi.org/10.3390/molecules24061174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471427/
https://www.ncbi.nlm.nih.gov/pubmed/30934584
http://dx.doi.org/10.3390/molecules24061174

Ejemplares similares