Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library...

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Detalles Bibliográficos
Autores principales: Perry, David L., Roberts, Bracken F., Debevec, Ginamarie, Michaels, Heather A., Chakrabarti, Debopam, Nefzi, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471430/
https://www.ncbi.nlm.nih.gov/pubmed/30897744
http://dx.doi.org/10.3390/molecules24061100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471430/
https://www.ncbi.nlm.nih.gov/pubmed/30897744
http://dx.doi.org/10.3390/molecules24061100

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