Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus

Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE-induced depression-like behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant...

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Autores principales: Zhang, Chong, Fan, Si-Jing, Sun, An-Bang, Liu, Zhen-Zhen, Liu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471439/
https://www.ncbi.nlm.nih.gov/pubmed/30942466
http://dx.doi.org/10.3892/mmr.2019.10105
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author Zhang, Chong
Fan, Si-Jing
Sun, An-Bang
Liu, Zhen-Zhen
Liu, Lian
author_facet Zhang, Chong
Fan, Si-Jing
Sun, An-Bang
Liu, Zhen-Zhen
Liu, Lian
author_sort Zhang, Chong
collection PubMed
description Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE-induced depression-like behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant rats twice daily from gestational day (GD) 9 to 20. In adolescent offspring, PNE significantly increased immobility time and decreased the sucrose preference in female rats. The numbers of hippocampal neurons declined in the CA3 and DG regions. Steroidogenic acute regulatory protein (StAR) expression was suppressed in female rats. In fetal offspring, the neuronal numbers of CA3 regions in PNE female fetal hippocampal were significantly decreased, accompanied by the enhanced content of corticosterone and StAR expression. These data indicated that PNE induced depression-like behavior in adolescent female rats via the regulation of neurosteroid levels in the hippocampus.
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spelling pubmed-64714392019-04-23 Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus Zhang, Chong Fan, Si-Jing Sun, An-Bang Liu, Zhen-Zhen Liu, Lian Mol Med Rep Articles Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE-induced depression-like behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant rats twice daily from gestational day (GD) 9 to 20. In adolescent offspring, PNE significantly increased immobility time and decreased the sucrose preference in female rats. The numbers of hippocampal neurons declined in the CA3 and DG regions. Steroidogenic acute regulatory protein (StAR) expression was suppressed in female rats. In fetal offspring, the neuronal numbers of CA3 regions in PNE female fetal hippocampal were significantly decreased, accompanied by the enhanced content of corticosterone and StAR expression. These data indicated that PNE induced depression-like behavior in adolescent female rats via the regulation of neurosteroid levels in the hippocampus. D.A. Spandidos 2019-05 2019-03-29 /pmc/articles/PMC6471439/ /pubmed/30942466 http://dx.doi.org/10.3892/mmr.2019.10105 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Chong
Fan, Si-Jing
Sun, An-Bang
Liu, Zhen-Zhen
Liu, Lian
Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title_full Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title_fullStr Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title_full_unstemmed Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title_short Prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
title_sort prenatal nicotine exposure induces depression-like behavior in adolescent female rats via modulating neurosteroid in the hippocampus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471439/
https://www.ncbi.nlm.nih.gov/pubmed/30942466
http://dx.doi.org/10.3892/mmr.2019.10105
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