Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, P(app,pig), were compared to the permeability coefficients determined in humans in vivo, P(eff,human). Eleven drugs from the different Biopharmaceutical Classific...

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Detalles Bibliográficos
Autores principales: Arnold, Yvonne E., Thorens, Julien, Bernard, Stéphane, Kalia, Yogeshvar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471532/
https://www.ncbi.nlm.nih.gov/pubmed/30901927
http://dx.doi.org/10.3390/pharmaceutics11030139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471532/
https://www.ncbi.nlm.nih.gov/pubmed/30901927
http://dx.doi.org/10.3390/pharmaceutics11030139

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