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Synthesis of lamellarin alkaloids using orthoester-masked α-keto acids

Pyruvic acid and other α-keto acids are frequently encountered as intermediates in metabolic pathways, yet their application in total synthesis has met with limited success. In this work, we present a bioinspired strategy that utilizes highly functionalized OBO (oxabicyclo[2.2.2]octyl) orthoester ma...

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Detalles Bibliográficos
Autores principales: Shirley, Harry J., Koyioni, Maria, Muncan, Filip, Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471603/
https://www.ncbi.nlm.nih.gov/pubmed/31057760
http://dx.doi.org/10.1039/c8sc05678a