Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination

A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were...

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Autores principales: Granados, Albert, Sarró, Pau, Vallribera, Adelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471818/
https://www.ncbi.nlm.nih.gov/pubmed/30909403
http://dx.doi.org/10.3390/molecules24061141
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author Granados, Albert
Sarró, Pau
Vallribera, Adelina
author_facet Granados, Albert
Sarró, Pau
Vallribera, Adelina
author_sort Granados, Albert
collection PubMed
description A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
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spelling pubmed-64718182019-04-26 Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination Granados, Albert Sarró, Pau Vallribera, Adelina Molecules Article A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions. MDPI 2019-03-22 /pmc/articles/PMC6471818/ /pubmed/30909403 http://dx.doi.org/10.3390/molecules24061141 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Granados, Albert
Sarró, Pau
Vallribera, Adelina
Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title_full Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title_fullStr Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title_full_unstemmed Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title_short Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
title_sort catalytic asymmetric fluorination of alkyl 1-indanone-2-carboxylates ruled by pybox-eu(iii) combination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471818/
https://www.ncbi.nlm.nih.gov/pubmed/30909403
http://dx.doi.org/10.3390/molecules24061141
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AT sarropau catalyticasymmetricfluorinationofalkyl1indanone2carboxylatesruledbypyboxeuiiicombination
AT vallriberaadelina catalyticasymmetricfluorinationofalkyl1indanone2carboxylatesruledbypyboxeuiiicombination

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