Spironolactone dose-dependently alleviates the calcification of aortic rings cultured in hyperphosphatemic medium with or without hyperglycemia by suppressing phenotypic transition of VSMCs through downregulation of Pit-1

Vascular calcification (VC) is highly prevalent in chronic kidney disease (CKD), especially in patients with end stage renal disease and is strongly associated with cardiovascular morbidity and mortality. Clinical observations have demonstrated that hyperphosphatemia and hyperglycemia can accelerate...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Quan, Zhengli, Luo, Dingshi, Chen, Wangshan, Peng, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471982/
https://www.ncbi.nlm.nih.gov/pubmed/30896801
http://dx.doi.org/10.3892/mmr.2019.10039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471982/
https://www.ncbi.nlm.nih.gov/pubmed/30896801
http://dx.doi.org/10.3892/mmr.2019.10039

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