d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

α-Conotoxin RgIA is a selective and potent competitive antagonist of rat α9α10 nicotinic acetylcholine receptors (nAChR), but it is much less potent towards human α9α10 nAChR. Furthermore, RgIA is susceptible to proteolytic degradation due to containing four arginine residues. These disadvantages gr...

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Detalles Bibliográficos
Autores principales: Ren, Jie, Zhu, Xiaopeng, Xu, Pan, Li, Rui, Fu, Ying, Dong, Shuai, Zhangsun, Dongting, Wu, Yong, Luo, Sulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472032/
https://www.ncbi.nlm.nih.gov/pubmed/30823399
http://dx.doi.org/10.3390/md17030142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472032/
https://www.ncbi.nlm.nih.gov/pubmed/30823399
http://dx.doi.org/10.3390/md17030142

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