SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

BACKGROUND: Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and signaling platforms. SCD1 overexpression functions as an oncogene in lung cancer an...

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Detalles Bibliográficos
Autores principales: She, Kelin, Fang, Shenghua, Du, Wei, Fan, Xingxing, He, Jiaxi, Pan, Hui, Huang, Liyan, He, Ping, Huang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472070/
https://www.ncbi.nlm.nih.gov/pubmed/31019378
http://dx.doi.org/10.1186/s12935-019-0809-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472070/
https://www.ncbi.nlm.nih.gov/pubmed/31019378
http://dx.doi.org/10.1186/s12935-019-0809-y

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