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Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines

Biocatalytic asymmetric amination of ketones, by using amine dehydrogenases (AmDHs) or transaminases, is an efficient method for the synthesis of α‐chiral primary amines. A major challenge is to extend amination to the synthesis of secondary and tertiary amines. Herein, for the first time, it is sho...

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Detalles Bibliográficos
Autores principales: Tseliou, Vasilis, Masman, Marcelo F., Böhmer, Wesley, Knaus, Tanja, Mutti, Francesco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472184/
https://www.ncbi.nlm.nih.gov/pubmed/30489013
http://dx.doi.org/10.1002/cbic.201800626