Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid

Camptothecin (CPT) shows potent anticancer activity through inhibition of topoisomerase I. However, its water insolubility and severe toxicity limit its clinical application. Coupling with bile acid moieties is a promising method for liver-targeted drug delivery, which takes advantage of the bile ac...

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Detalles Bibliográficos
Autores principales: Xiao, Linxia, Yu, Endian, Yue, Hanlin, Li, Qingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472190/
https://www.ncbi.nlm.nih.gov/pubmed/30917485
http://dx.doi.org/10.3390/molecules24061179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472190/
https://www.ncbi.nlm.nih.gov/pubmed/30917485
http://dx.doi.org/10.3390/molecules24061179

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