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Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans

The asparagine (N)-linked Man9GlcNAc2 is required for glycoprotein folding and secretion. Understanding how its structure contributes to these functions has been stymied by our inability to produce this glycan as a homogenous structure of sufficient quantities for study. Here, we report the high yie...

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Detalles Bibliográficos
Autores principales: Li, Sheng-Tao, Lu, Tian-Tian, Xu, Xin-Xin, Ding, Yi, Li, Zijie, Kitajima, Toshihiko, Dean, Neta, Wang, Ning, Gao, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472349/
https://www.ncbi.nlm.nih.gov/pubmed/31000718
http://dx.doi.org/10.1038/s41467-019-09752-3