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An information theoretic phase I–II design for molecularly targeted agents that does not require an assumption of monotonicity
For many years phase I and phase II clinical trials have been conducted separately, but there has been a recent shift to combine these phases. Although a variety of phase I–II model‐based designs for cytotoxic agents have been proposed in the literature, methods for molecularly targeted agents (TAs)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472641/ https://www.ncbi.nlm.nih.gov/pubmed/31007292 http://dx.doi.org/10.1111/rssc.12293 |