APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol tr...

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Detalles Bibliográficos
Autores principales: Ryu, Jung-Hwa, Ge, Mengyuan, Merscher, Sandra, Rosenberg, Avi Z., Desante, Marco, Roshanravan, Hila, Okamoto, Koji, Shin, Myung K., Hoek, Maarten, Fornoni, Alessia, Kopp, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472726/
https://www.ncbi.nlm.nih.gov/pubmed/30998685
http://dx.doi.org/10.1371/journal.pone.0211559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472726/
https://www.ncbi.nlm.nih.gov/pubmed/30998685
http://dx.doi.org/10.1371/journal.pone.0211559

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