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Ranking Hits From Saturation Transfer Difference Nuclear Magnetic Resonance–Based Fragment Screening
Fragment-based screening is an established route to identify low-molecular-weight molecules to generate high-affinity inhibitors in drug discovery. The affinities of these early hits from fragment screenings require a highly sensitive biophysical screening technique. Saturation transfer difference (...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473174/ https://www.ncbi.nlm.nih.gov/pubmed/31032246 http://dx.doi.org/10.3389/fchem.2019.00215 |