Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome

Gain-of-function variants in p110δ, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) expressed in lymphocytes, cause activated PI3-kinase δ syndrome (APDS), a primary immunodeficiency that is characterized by recurrent infections, viremia, lymphadenopathy, and autoimmunity. The mechanis...

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Detalles Bibliográficos
Autores principales: Thauland, Timothy J., Pellerin, Laurence, Ohgami, Robert S., Bacchetta, Rosa, Butte, Manish J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473200/
https://www.ncbi.nlm.nih.gov/pubmed/31031754
http://dx.doi.org/10.3389/fimmu.2019.00753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473200/
https://www.ncbi.nlm.nih.gov/pubmed/31031754
http://dx.doi.org/10.3389/fimmu.2019.00753

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