Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have revealed that extracellular ATP, through its selective receptor P2X7 (P2X7R), is esse...

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Detalles Bibliográficos
Autores principales: Martínez-Frailes, Carlos, Di Lauro, Caterina, Bianchi, Carolina, de Diego-García, Laura, Sebastián-Serrano, Álvaro, Boscá, Lisardo, Díaz-Hernández, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474397/
https://www.ncbi.nlm.nih.gov/pubmed/31031598
http://dx.doi.org/10.3389/fncel.2019.00143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474397/
https://www.ncbi.nlm.nih.gov/pubmed/31031598
http://dx.doi.org/10.3389/fncel.2019.00143

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