Survival of Mycobacterium bovis BCG oral vaccine during transit through a dynamic in vitro model simulating the upper gastrointestinal tract of badgers

In developing an oral bait BCG vaccine against tuberculosis in badgers we wanted to understand the conditions of the gastrointestinal tract and their impact on vaccine viability. Conditions mimicking stomach and small-intestine caused substantial reduction in BCG viability. We performed in vivo expe...

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Detalles Bibliográficos
Autores principales: Williams, Gareth A., Koenen, Marjorie E., Havenaar, Robert, Wheeler, Paul, Gowtage, Sonya, Lesellier, Sandrine, Chambers, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474584/
https://www.ncbi.nlm.nih.gov/pubmed/31002668
http://dx.doi.org/10.1371/journal.pone.0214859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474584/
https://www.ncbi.nlm.nih.gov/pubmed/31002668
http://dx.doi.org/10.1371/journal.pone.0214859

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