NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells

Alternative splicing is dysregulated in cancer cells, driving the production of isoforms that allow tumor cells to survive and continuously proliferate. Part of the reactivation of telomerase involves the splicing of hTERT transcripts to produce full-length (FL) TERT. Very few splicing factors to da...

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Detalles Bibliográficos
Autores principales: Sayed, Mohammed E., Yuan, Laura, Robin, Jerome D., Tedone, Enzo, Batten, Kimberly, Dahlson, Nicole, Wright, Woodring E., Shay, Jerry W., Ludlow, Andrew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474811/
https://www.ncbi.nlm.nih.gov/pubmed/30568224
http://dx.doi.org/10.1038/s41388-018-0639-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474811/
https://www.ncbi.nlm.nih.gov/pubmed/30568224
http://dx.doi.org/10.1038/s41388-018-0639-8

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