A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

Here we demonstrate a mode of reciprocal regulation between GFI1 and p53 that controls the induction of apoptosis in T cells. We show that GFI1 prevents induction of p53 dependent apoptosis by recruiting LSD1 to p53, which leads to the demethylation of its C-terminal domain. This is accompanied by a...

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Detalles Bibliográficos
Autores principales: Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Hamard, Pierre-Jacques, Manfredi, James J., Möröy, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474872/
https://www.ncbi.nlm.nih.gov/pubmed/31004086
http://dx.doi.org/10.1038/s41598-019-41684-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474872/
https://www.ncbi.nlm.nih.gov/pubmed/31004086
http://dx.doi.org/10.1038/s41598-019-41684-2

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