Quantification of subclonal selection in cancer from bulk sequencing data

Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary dynamics that produce tumour subclones remain unknown. Here we measure clone dynamics in human cancers using computational modelling of subclonal selection and theoretical population genetics applied to hig...

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Detalles Bibliográficos
Autores principales: Williams, Marc J., Werner, Benjamin, Heide, Timon, Curtis, Christina, Barnes, Chris P, Sottoriva, Andrea, Graham, Trevor A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475346/
https://www.ncbi.nlm.nih.gov/pubmed/29808029
http://dx.doi.org/10.1038/s41588-018-0128-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475346/
https://www.ncbi.nlm.nih.gov/pubmed/29808029
http://dx.doi.org/10.1038/s41588-018-0128-6

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