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Quantification of subclonal selection in cancer from bulk sequencing data
Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary dynamics that produce tumour subclones remain unknown. Here we measure clone dynamics in human cancers using computational modelling of subclonal selection and theoretical population genetics applied to hig...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475346/ https://www.ncbi.nlm.nih.gov/pubmed/29808029 http://dx.doi.org/10.1038/s41588-018-0128-6 |