Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response

A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter receptor linked to cognitive function, mental h...

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Detalles Bibliográficos
Autores principales: Costantini, Todd W., Chan, Theresa W., Cohen, Olga, Langness, Simone, Treadwell, Sabrina, Williams, Elliot, Eliceiri, Brian P., Baird, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475388/
https://www.ncbi.nlm.nih.gov/pubmed/30944217
http://dx.doi.org/10.1073/pnas.1821853116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475388/
https://www.ncbi.nlm.nih.gov/pubmed/30944217
http://dx.doi.org/10.1073/pnas.1821853116

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