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Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response
A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter receptor linked to cognitive function, mental h...
Autores principales: | Costantini, Todd W., Chan, Theresa W., Cohen, Olga, Langness, Simone, Treadwell, Sabrina, Williams, Elliot, Eliceiri, Brian P., Baird, Andrew |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475388/ https://www.ncbi.nlm.nih.gov/pubmed/30944217 http://dx.doi.org/10.1073/pnas.1821853116 |
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