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rpoB Mutations Causing Discordant Rifampicin Susceptibility in Mycobacterium tuberculosis: Retrospective Analysis of Prevalence, Phenotypic, Genotypic, and Treatment Outcomes

BACKGROUND: Discordant genotypic/phenotypic rifampicin susceptibility testing in Mycobacterium tuberculosis is a significant challenge, yet there are limited data on its prevalence and how best to manage such patients. Whether to treat isolates with rpoB mutations not conferring phenotypic resistanc...

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Detalles Bibliográficos
Autores principales: Mvelase, Nomonde R, Pillay, Melendhran, Sibanda, Wilbert, Ngozo, Jacqueline N, Brust, James C M, Mlisana, Koleka P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475586/
https://www.ncbi.nlm.nih.gov/pubmed/31024968
http://dx.doi.org/10.1093/ofid/ofz065