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Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is mainly caused by mutations in sarcomeric proteins. Thirty to forty percent of identified mutations are found in the ventricular myosin heavy chain (β-MyHC). A common mechanism explaining how numerous mutations in several different proteins induce a similar HCM-ph...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475633/ https://www.ncbi.nlm.nih.gov/pubmed/30740621 http://dx.doi.org/10.1007/s00424-019-02260-9 |